The tournament will see many Premier League stars join their national teams, with some clubs set to lose multiple players.

Below is a list of Premier League clubs and the players who will be departing for AFCON:

Arsenal: No players will be representing African nations in their first-team squad.

Aston Villa: Evann Guessand will be joining the Ivory Coast squad.

Bournemouth: Amine Adli has been called up for Morocco, while Antoine Semenyo will remain with the club after Ghana failed to qualify.

Brentford: Dango Ouattara and Frank Onyeka have both been selected for their respective national teams.

Brighton: Carlos Baleba will be part of Cameroon's squad, while Yankuba Minteh will stay with the Seagulls after Gambia failed to qualify.

Burnley: Lyle Foster, Axel Tuanzebe, and Hannibal Mejbri will be representing their national teams.

Chelsea: No players from Chelsea will be representing African nations in their first-team squad.

Crystal Palace: Chadi Riad and Chieck Doucoure are injury concerns, while Ismaila Sarr will be joining Senegal despite being injured.

Everton: Iliman Ndiaye and Idrissa Gueye will be representing Senegal, while Adam Aznou was not called up for Morocco.

Fulham: Alex Iwobi, Calvin Bassey, and Samuel Chukwueze will all be part of Nigeria's side.

Leeds: No players from Leeds will be representing African nations in their first-team squad.

Liverpool: Mohamed Salah will be representing Egypt.

Manchester City: Omar Marmoush and Rayan Ait-Nouri will be joining their respective national teams.

Manchester United: Amad Diallo, Bryan Mbeumo, and Noussair Mazraoui will be heading to AFCON.

Newcastle: Yoane Wissa was not selected for DR Congo due to injury.

Nottingham Forest: Taiwo Awoniyi and Ola Aina were not included in Nigeria's final squad, while Ibrahim Sangare and Willy Boly will be representing the Ivory Coast.

Sunderland: Six players will be departing for AFCON, including Noah Sadiki, Arthur Masuaku, Bertrand Traore, Chemsdine Talbi, Reinildo Mandava, and Habib Diarra.

Tottenham Hotspur: Pape Matar Sarr and Yves Bissouma will be representing their national teams.

West Ham: Aaron Wan-Bissaka and El Hadji Malick Diouf will be joining their respective national teams.

Wolves: Two players, Tawanda Chirewa and Emmanuel Agbadou, will be representing their national teams, while Tolu Arokodare and Jackson Tchatchoua were not selected.