Teenager Lamine Yamal, who recently returned from rehabilitation, is struggling with a lingering groin issue, while other key players like Frenkie de Jong, Jules Kounde, Alejandro Balde, and Fermin Lopez have also faced injury setbacks.
Elche, who are eighth in the standings with 14 points from 10 matches, are looking to capitalize on Barcelona's injury crisis. They have been one of the season's surprise packages and are just two points off the European qualification spots.
Meanwhile, Real Madrid, who are top of the table, will host Valencia on Saturday. Despite their excellent run, tensions have arisen within the team following a recent incident involving Brazilian winger Vinicius Jr. The player has apologized for his actions but has not commented on the team's manager, Xabi Alonso.
Alonso has stated that the matter will be handled internally, and the team may make changes to their squad for the upcoming match. With a Champions League clash against Liverpool scheduled for Tuesday, Alonso may choose to rotate his players.
Valencia, who are 18th in LaLiga with nine points, are struggling to avoid relegation and are winless in nearly six weeks. They will face a tough test against Real Madrid, who are looking to maintain their lead at the top of the table.
Other matches in LaLiga include Villarreal hosting Rayo Vallecano and Atletico Madrid welcoming Sevilla to the Metropolitano Stadium. Both teams will look to close the gap on the top two.
