After the break, Ferdinand Pohl doubled Bayer's lead, giving his team control of the game.

Despite a late goal from Kyle Fitzgerald, Newcastle was unable to catch up, and Bayer Leverkusen secured the win.

Isaac Moran, who joined Newcastle from Liverpool in the summer, made his UYL debut in the match.

Thomas Bryant, who had been recovering from a long-term injury, earned his first competitive start in 362 days.